5 Preservative-Free Eye Drops That Work Best For Dry & Sensitive Eyes

People suffering from dry eye nowadays can easily look for over-the-counter eye drops everywhere in drugstores or online shops. But most of them have preservatives that can cause irritations to eyes especially when their eyes are too sensitive. So, this article will help to find​ Best Free-Preservative Eye Drops For Mild And Severe Dryness and sensitive Eyes.

Preservatives are some kinds of chemical that was often added to eye drops to help prevent bacteria or fungi. ​​​If you notice ​the inactive ingredients of eye drops, you often see one or some of preservatives ​including:

  • ​Benzalkonium chloride (BAK)
  • ​Polyquad
  • ​Sodium Perborate
  • GenAqua (Sodium Perborate)
  • Purite (Stabilized Oxychloro Complex)
  • Edetate Disodium
  • Sorbic Acid
  • Dequest (Sodium Perborate)
  • Polixetonium (Polyquarternium-42)
  • OcuPure (Stabilized Oxychloro Complex)

​While multi-​functional ​tear ​drops are required to have preservatives for hygienic purpose and keeping the medications sterile, usage of preservatives can cause some side effects to dry eye including reduction of the desired effect, allergic response, and toxic reaction. According to experts, eye drops with preservatives ​​are not suitable for dry sensitive eyes in ​several cases.

If you have irritation with preservatives or get frequent dry eye from mild to severe mild cases, then you should opt for preservative-free eye drops. This is good because you can apply the drops for more times during the day. These products cause no irritations and are ​suitable for most dry eye syndromes from mild to severe cases. ​

Here is your quick guide to pick the most suitable product for yourself

At A Glance: Our Choices for ​5 Best free-preservative Eye Drops For ​sensitive Dry Eyes.

If you are already a fan of Bausch & Lomb,  you cannot go wrong with this Bausch & Lomb Soothe Lubricant Eye Drops. The single-use dispenser is convenient, good for mild dry eye, LASIK dryness and great for packing along while driving a long distance.

Next Thera Tears Lubricant Eye Drops will be your best choice for your severe dry eye. It’s also good if your eyes are too sensitive to other eye drops.

​When you are looking for a versatile product that can handle most of symptoms from dryness, redness and irritation, go with Refresh Optive Advanced Lubricant Eye Drops.

In case you prefer some kind of ​extended protection and high-performance relief, this Systane Ultra Lubricant Eye Drops with breakthrough technology will ​guarantee ​a full protection for your eyes.

For those who like long-lasting effect and frequent have severe dry eye, Bion Tears Lubricant Eye Drops with its unique formula is sure to fit with your needs.

Review of the best preservative-free eye drops For mild and severe Dry Eyes


​Key Features (*)

#1 - ​​Soothe

Bausch & Lomb Soothe Lubricant Eye Drops
  • Type: ​Lubricant eye drops
  • ​Size: 0.02 oz (0.6 ml)/​vial
  • ​Preservative free
  • ​Good for LASIK dryness

#2 - ​Thera Tears 

  • Type: ​Lubricant eye drops
  • ​Size: 0.02 oz (0.6 ml)/vial
  • Preservative free
  • ​Doctor recommended

#3 - ​Refresh ​Advanced 

Refresh Optive Advanced Lubricant Eye Drops
  • Type: ​Lubricant eye drops
  • ​Size: 0.01 oz (0.4 ml)/vial
  • ​Preservative free
  • ​Triple-action relief

#4 - ​Systane Ultra

Systane Ultra Lubricant Eye Drops
  • Type: ​Lubricant eye drops
  • ​Size: ​0.7 mL/vial)
  • ​Preservative free
  • ​Extended protection

#5 - ​Bion Tears

Bion Tears Lubricant Eye Drops
  • Type: ​Lubricant eye drops
  • ​Size: ​0.015 oz/vial
  • ​Preservative free
  • ​Best for ​severe dryness
​(*) Note: The description and specifications of products are updated as the time of editor's article. However they are the subject for changes over time. Please read the product descriptions carefully before you buy any recommended product​.

Here, the 5 ​best preservative-free tear drops for​ ​dry and fragile eyes on OTC (over-the-counter) market that can make you never want to ​switch back to your old ​drops:

#1 ​Bausch & Lomb Soothe Lubricant Eye Drops

This unique formula will make sure to restore and balance the moisture in your eyes. ​

The product contains some active ingredients such as Glycerin and Propylene Glycol to enhance performance as well as provide protection further.

Bausch & Lomb Soothe Lubricant Eye Drops

This eye drops is great for mild dry eye and some other cases such as redness, tired eyes or irritation caused by overusing the eyes, driving long distances and dust particles. Each package comes with 28 single-use vials, it’s value size and convenient for use.

​What we like:

  • ​Good reputation brand
  • ​Good for Lasik dryness
  • ​Quick relief and long-lasting effect
  • ​Affordable Price

​​What we didn't like

  • ​Need to re-use the caps
  • ​May cause waste of liquid

#2 ​ThereTears Lubricant Eye Drops

Thera Tears is a highly recommended eye drops with electrolyte balance patent.

The product was developed by a prominent ophthalmologist after 18 years of research. Drops are sterile and completely safe for those who have sensitive eyesight.


The product comes with 24-32 vials per box and provide immediate and long effect to your eyes. The unique formulate that replicates natural tears will soothe and keep the relief effect last longer.

Thera Tears work best for any severe dry eye cases.

​What we like:

  • ​Preservative free 
  • ​Highly recommended
  • ​Suitable for sensitive eyes
  • ​Fast-acting effect on symptoms

​​What we didn't like

  • ​Frequently I don't use up the vial
  • ​Not work for every symptom

#3 Refresh Optive Advanced Lubricant Eye Drops

This 30 single-use sterile vials is an excellent choice for any mild cases from dryness, redness and irritation.

Besides, it is the most recommended artificial eye drops by specialists.

One of its distinctive features is to prevent your tears from quickly evaporating.

Refresh Optive Advanced Lubricant Eye Drops

Refresh Optive Advanced can work well on all three layers of the tear film by its triple-action formula. Firstly, it lubricates to provide moisture then hydrated the eyes’ cells on the surface. And finally, it protects the natural tears from evaporating.

​What we like:

  • ​Used for many symptoms
  • ​Most recommended by specialists
  • ​Triple-action formula for the tear firm
  • ​Affordable price

​​What we didn't like

  • ​May feel slight burn for ​short time
  • ​Need the test, whether it works or not

#4 ​Systane Ultra Lubricant Eye Drops​

Systane ultra is quite common among eye drops products. There are many types of them on the market. Those are free-preservative usually come in vials.

They provide instant effect and offer fully protection to your eyes with high performance.

Systane Ultra Lubricant Eye Drops

The product is prepared with Systance’s breakthrough technology that promises to protect the ocular surface. ​This lubricating eye drops leave eyes feeling refreshed, bringing you relief and lasting protection against mild dry eye symptoms.

​What we like:

  • ​Preservative free
  • ​Immediate effect after applying
  • ​Further protection
  • ​Systane Ultra’s breakthrough technology

​​What we didn't like

  • ​May cause eyelashes sticky
  • ​Causes itchiness when overused

#​5 ​Bion Tears Lubricant Eye Drops

This eye drops is used to relieve dry and irritated eyes. It offers a long-lasting eye relief effect for your eyesight as well as further protection from other common eye syndromes.

This product is suitable for severe dry eyes.

The unique formula promotes eyes lubricant to keep the moisture in the eyes and help to protect it from infection.

Bion Tears Lubricant Eye Drops

​Bion Tears offers 28 single-use vials, 0,4 ml each. ​This product contains glycerin with polysorbates, it may appear milky. But Bion Tears is totally safe for those whose eyes are sensitive.

​What we like:

  • ​Good brand name - Alcon
  • ​Suitable for severe dry eye
  • ​Long-lasting relief effect
  • ​Good for sensitive eyes

​​What we didn't like

  • Complaint of brief burning sensation
  • ​Vials are not full

​Comparisons ​Chart: What Is The ​Best Preservative-free Eye Drops For ​​​Sensitive & dry eyes?


Best Overall

​2nd choice

3rd choice

4th choice

5th choice

Top-Rated ​

Eye Drops For ​
​Mild​ Severe 
Dry Eye
Bausch & Lomb Soothe Lubricant Eye Drops
Refresh Optive Advanced Lubricant Eye Drops
Systane Ultra Lubricant Eye Drops
Bion Tears Lubricant Eye Drops



​Thera Tears



​Bion Tears

​Editor's rating







​Best for

​Mild dry eye

​Lasik dryness

​Sensitive eyes

​Severe dry eye

​Mild dry eye

​Mild dry eye

Extended protection

​​Severe dry eye


0.02 oz (0.6ml)​

0.02 oz (0.6ml)

0.01 oz (0.4ml)

0.7 ml

​0.015oz (0.4ml)


Multi packs

​Multi packs

​Multi packs

​Multi packs

​Multi packs

​Get started

​Buy Now

​​Buy Now

​​Buy Now

​​Buy Now

​​Buy Now


Patients quite often experience dry eyes after LASIK surgery, thus we highly recommend these people to use free-preservative eye drops. Especially when your eyes have irritation, even a little amount of preservative could cause further discomfort if you use it long enough.

We also suggest you can start with aqueous eye drops if you are not really sure what is causing the dryness in your eyes. However, if the problem does not go away, you should seek for specialists.

But for now, we want to pick Bausch & Lomb Soothe Lubricant Eye Drops as best product for dry eye in mid case, Lasik dryness and Sensitive eyes. The reason why we choose this eye drops because it is a lipid-based drops product and it strengthens the tear film and promote cell growth. It is suitable for using on a regular basis and is very effective for dry eye.

That's our decision about the best eye drops without preservatives for you. What do you have in your mind now? 

We would love to hear from your personal experience after trying out these products, don't forget to leave us a comment below.


Giới thiệu: Bo Yong

I'm the founder and owner of Thank Your Eyes. I have been nearsighted since I was a child, so I had eye surgery with LASIK method but it was damaged so I had to undergo additional surgery. Fortunately, this time my eyes were clear again. With this blog, I want to share my experiences with anyone who is having eye problems and wants to have healthy eyes.

Bình luận bài viết này

0 Chia Sẻ
Chia Sẻ
Chia Sẻ